Team / Team Members

Affiliated Faculty

Alex Charney

Assistant Professor

Bio

Alexander Charney, MD, PhD, is an Assistant Professor at the Icahn School of Medicine with primary appointments in the Departments of Psychiatry and Genetics & Genomic Sciences, as well as secondary appointments in the Departments of Neuroscience and Neurosurgery. He received his MD and PhD under the mentorship of Pamela Sklar, MD, PhD, and Eric Schadt, PhD, two of the world’s foremost experts on large-scale genomics and multiscale biology. He has been the lead data scientist on some of the largest genetic studies ever conducted on schizophrenia and bipolar disorder, including genome-wide association studies, copy number variant studies and rare sequencing variant studies. Currently, he leads several of the largest studies in the field of psychiatric genomics and has established a unique approach to human brain research as the founder and primary investigator of the Living Brain Project. As a physician-scientist specializing in the neurobiology of severe mental illness, his primary goal is to translate genomic discoveries to experimental therapeutics.

Bio

Alexander Charney, MD, PhD, is an Assistant Professor at the Icahn School of Medicine with primary appointments in the Departments of Psychiatry and Genetics & Genomic Sciences, as well as secondary appointments in the Departments of Neuroscience and Neurosurgery. He received his MD and PhD under the mentorship of Pamela Sklar, MD, PhD, and Eric Schadt, PhD, two of the world’s foremost experts on large-scale genomics and multiscale biology. He has been the lead data scientist on some of the largest genetic studies ever conducted on schizophrenia and bipolar disorder, including genome-wide association studies, copy number variant studies and rare sequencing variant studies. Currently, he leads several of the largest studies in the field of psychiatric genomics and has established a unique approach to human brain research as the founder and primary investigator of the Living Brain Project. As a physician-scientist specializing in the neurobiology of severe mental illness, his primary goal is to translate genomic discoveries to experimental therapeutics.

Publications

March, 2021

Outcomes of Patients on Maintenance Dialysis Hospitalized with COVID-19

Journal | CJASN

HPI·MS Authors

Zahi Fayad

Erwin Bottinger

Alex Charney

Girish Nadkarni

4 HPI•MS authors

Full list of authors

Lili Chan, Suraj K Jaladanki, Sulaiman Somani, Ishan Paranjpe, Arvind Kumar, Shan Zhao, Lewis Kaufman, Staci Leisman, Shuchita Sharma, John Cijiang He, Barbara Murphy, Zahi A Fayad, Matthew A Levin, Erwin P Bottinger, Alexander W Charney, Benjamin S Glicksberg, Steven G Coca, Girish N Nadkarni

Journal

CJASN

Open Publication

February, 2021

Association of SARS-CoV-2 viral load at admission with in-hospital acute kidney injury: A retrospective cohort study

Journal | PLOS ONE

HPI·MS Authors

Erwin Bottinger

Zahi Fayad

Alex Charney

Girish Nadkarni

4 HPI•MS authors

Full list of authors

Ishan Paranjpe, Kumardeep Chaudhary, Kipp W. Johnson, Suraj K. Jaladanki, Shan Zhao, Jessica K. De Freitas, Elisabet Pujdas, Fayzan Chaudhry, Erwin P. Bottinger, Matthew A. Levin, Zahi A. Fayad, Alexander W. Charney, Jane Houldsworth, Carlos Cordon-Cardo, Benjamin S. Glicksberg, Girish N. Nadkarni

Journal

PLOS ONE

Open Publication

February, 2021

Use of Physiological Data From a Wearable Device to Identify SARS-CoV-2 Infection and Symptoms and Predict COVID-19 Diagnosis: Observational Study

Journal | Journal of Medical Internet Research

HPI·MS Authors

Robert Hirten

Matteo Danieletto

Micol Zweig

Sparshdeep (Shelly) Kaur

Alex Charney

Erwin Bottinger

Girish Nadkarni

Zahi Fayad

8 HPI•MS authors

Full list of authors

Robert P Hirten; Matteo Danieletto; Lewis Tomalin; Katie Hyewon Choi; Micol Zweig; Eddye Golden; Sparshdeep Kaur; Drew Helmus; Anthony Biello; Renata Pyzik; Alexander Charney; Riccardo Miotto; Benjamin S Glicksberg; Matthew Levin; Ismail Nabeel; Judith Aberg; David Reich; Dennis Charney; Erwin P Bottinger; Laurie Keefer; Mayte Suarez-Farinas; Girish N Nadkarni; Zahi A Fayad

Journal

Journal of Medical Internet Research

Open Publication

January, 2021

Federated Learning of Electronic Health Records to Improve Mortality Prediction in Hospitalized Patients With COVID-19: Machine Learning Approach

Journal | JMIR Med Inform

HPI·MS Authors

Alex Charney

Erwin Bottinger

Zahi Fayad

Girish Nadkarni

4 HPI•MS authors

Full list of authors

Akhil Vaid, Suraj K Jaladanki, Jie Xu, Shelly Teng, Arvind Kumar, Samuel Lee, Sulaiman Somani, Ishan Paranjpe, Jessica K De Freitas, Tingyi Wanyan, Kipp W Johnson, Mesude Bicak, Eyal Klang, Young Joon Kwon, Anthony Costa, Shan Zhao, Riccardo Miotto, Alexander W Charney, Erwin Böttinger, Zahi A Fayad, Girish N Nadkarni, Fei Wang, Benjamin S Glicksberg

Journal

JMIR Med Inform

Open Publication

January, 2021

AKI in Hospitalized Patients with COVID-19

Journal | Journal of the American Society of Nephrology

HPI·MS Authors

Zahi Fayad

Alex Charney

Erwin Bottinger

Girish Nadkarni

4 HPI•MS authors

Full list of authors

Lili Chan, Kumardeep Chaudhary, Aparna Saha, Kinsuk Chauhan, Akhil Vaid, Shan Zhao, Ishan Paranjpe, Sulaiman Somani, Felix Richter, Riccardo Miotto, Anuradha Lala, Arash Kia, Prem Timsina, Li Li, Robert Freeman, Rong Chen, Jagat Narula, Allan C. Just, Carol Horowitz, Zahi Fayad, Carlos Cordon-Cardo, Eric Schadt, Matthew A. Levin, David L. Reich, Valentin Fuster, Barbara Murphy, John C. He, Alexander W. Charney, Erwin P. Böttinger, Benjamin S. Glicksberg, Steven G. Coca, Girish N. Nadkarni and on behalf of the Mount Sinai COVID Informatics Center (MSCIC)

Journal

Journal of the American Society of Nephrology

Open Publication

November, 2020

Retrospective cohort study of clinical characteristics of 2199 hospitalised patients with COVID-19 in New York City

Journal | BMJ Open

HPI·MS Authors

Matteo Danieletto

Manbir Singh

Zahi Fayad

Erwin Bottinger

Alex Charney

Girish Nadkarni

6 HPI•MS authors

Full list of authors

Ishan Paranjpe, Adam J Russak, Jessica K De Freitas, Anuradha Lala, Riccardo Miotto, Akhil Vaid, Kipp W Johnson, Matteo Danieletto, Eddye Golden, Dara Meyer, Manbir Singh, Sulaiman Somani, Arjun Kapoor, Ross O'Hagan, Sayan Manna, Udit Nangia, Suraj K Jaladanki, Paul O’Reilly, Laura M Huckins, Patricia Glowe, Arash Kia, Prem Timsina, Robert M Freeman, Matthew A Levin, Jeffrey Jhang, Adolfo Firpo, Patricia Kovatch, Joseph Finkelstein, Judith A Aberg, Emilia Bagiella, Carol R Horowitz, Barbara Murphy, Zahi A Fayad, Jagat Narula, Eric J Nestler, V Fuster, Carlos Cordon-Cardo, Dennis Charney, David L Reich, Allan Just, Erwin P Bottinger, Alexander W Charney, Benjamin S Glicksberg, Girish N Nadkarni

Journal

BMJ Open

Open Publication

November, 2020

Machine Learning to Predict Mortality and Critical Events in a Cohort of Patients With COVID-19 in New York City: Model Development and Validation

Journal | JMIR Medical Informatics

HPI·MS Authors

Matteo Danieletto

Manbir Singh

Erwin Bottinger

Zahi Fayad

Alex Charney

Girish Nadkarni

6 HPI•MS authors

Full list of authors

Akhil Vaid, Sulaiman Somani, Adam J Russak, Jessica K De Freitas, Fayzan F Chaudhry, Ishan Paranjpe, Kipp W Johnson, Samuel J Lee, Riccardo Miotto, Shan Zhao, Noam Beckmann, Nidhi Naik, Kodi Arfer, Arash Kia, Prem Timsina, Anuradha Lala, Manish Paranjpe, Patricia Glowe, Eddye Golden, Matteo Danieletto, Manbir Singh, Dara Meyer, Paul F O'Reilly, Laura H Huckins, Patricia Kovatch, Joseph Finkelstein, Robert M Freeman, Edgar Argulian, Andrew Kasarskis, Bethany Percha, Judith A Aberg, Emilia Bagiella, Carol R Horowitz, Barbara Murphy, Eric J Nestler, Eric E Schadt, Judy H Cho, Carlos Cordon-Cardo, Valentin Fuster, Dennis S Charney, David L Reich, Erwin P Bottinger, Matthew A Levin, Jagat Narula, Zahi A Fayad, Allan Just, Alexander W Charney, Girish N Nadkarni, Benjamin S Glicksberg

Journal

JMIR Medical Informatics

Open Publication

October, 2020

Hospitalised COVID-19 patients of the Mount Sinai Health System: a retrospective observational study using the electronic medical records

Journal | BMJ Open

HPI·MS Authors

Alex Charney

Girish Nadkarni

2 HPI•MS authors

Full list of authors

Zichen Wang, Amanda Zheutlin, Yu-Han Kao, Kristin Ayers, Susan Gross, Patricia Kovatch, Sharon Nirenberg, Alexander Charney, Girish Nadkarni, Jessica K De Freitas, Paul O'Reilly, Allan Just, Carol Horowitz, Glenn Martin , Andrea Branch, Benjamin S Glicksber, Dennis Charney, David Reich, William K Oh, Eric Schadt, Rong Chen, Li Li

Journal

BMJ Open

Open Publication

October, 2020

Anticoagulation, Bleeding, Mortality, and Pathology in Hospitalized Patients With COVID-19

Journal | JACC

HPI·MS Authors

Girish Nadkarni

Alex Charney

Zahi Fayad

3 HPI•MS authors

Full list of authors

Girish N Nadkarni, Anuradha Lala, Emilia Bagiella, Helena L Chang, Pedro Moreno, Elisabet Pujadas, Varun Arvind, Sonali Bose, Alexander W Charney, Martin D Chen, Carlos Cordon-Cardo, Andrew S Dunn, Michael E Farkouh, Benjamin Glicksberg, Arash Kia, Roopa Kohli-Seth, Matthew A Levin, Prem Timsina, Shan Zhao, Zahi A Fayad, Valentin Fuster

Journal

JACC

Open Publication

August, 2020

Characterization of Patients Who Return to Hospital Following Discharge from Hospitalization For COVID-19

Journal | Journal of General Internal Medicine

HPI·MS Authors

Erwin Bottinger

Zahi Fayad

Alex Charney

Girish Nadkarni

4 HPI•MS authors

Full list of authors

Sulaiman Somani, Felix Richter, Valentin Fuster, Jessica De Freitas, Nidhi Naik, Keith Sigel, Mount Sinai Covid Informatics Center, Erwin P Boettinger, Matthew A Levin, Zahi Fayad, Allan C Just, Alexander Charney, Shan Zhao, Benjamin S Glicksberg, Anuradha Lala, Girish Nadkarni

Journal

Journal of General Internal Medicine

Open Publication

August, 2020

Prevalence and Impact of Myocardial Injury in Patients Hospitalized With COVID-19 Infection

Journal | Journal of the American College of Cardiology

HPI·MS Authors

Zahi Fayad

Alex Charney

Girish Nadkarni

3 HPI•MS authors

Full list of authors

Anuradha Lala, Kipp W Johnson, James L Januzzi, Adam J Russak, Ishan Paranjpe, Felix Richter, Shan Zhao, Sulaiman Somani, Tielman Van Vleck, Akhil Vaid, Fayzan Chaudhry, Jessica K De Freitas, Zahi A Fayad, Sean P Pinney, Matthew Levin, Alexander Charney, Emilia Bagiella, Jagat Narula, Benjamin S Glicksberg, Girish Nadkarni, Donna M Mancini, Valentin Fuster, Mount Sinai Covid Informatics Center

Journal

Journal of the American College of Cardiology

Open Publication

August, 2020

Prevalence and impact of myocardial injury in patients hospitalized with COVID-19 infection

Journal | JACC

HPI·MS Authors

Zahi Fayad

Alex Charney

Girish Nadkarni

3 HPI•MS authors

Full list of authors

Anuradha Lala, Kipp W Johnson, James L Januzzi, Adam J Russak, Ishan Paranjpe, Felix Richter, Shan Zhao, Sulaiman Somani, Tielman Van Vleck, Akhil Vaid, Fayzan Chaudhry, Jessica K De Freitas, Zahi A Fayad, Sean P Pinney, Matthew Levin, Alexander Charney, Emilia Bagiella, Jagat Narula, Benjamin S Glicksberg, Girish Nadkarni, Donna M Mancini, Valentin Fuster, Mount Sinai COVID Informatics Center

Journal

JACC

Open Publication

July, 2020

Sampling the Host Response to SARS-CoV-2 in Hospitals Under Siege

Journal | Nature Medicine

HPI·MS Authors

Alex Charney

Girish Nadkarni

2 HPI•MS authors

Full list of authors

Alexander W. Charney, Nicole W. Simons, Konstantinos Mouskas, Lauren Lepow, Esther Cheng, Jessica Le Berichel, Christie Chang, Robert Marvin, Diane Marie Del Valle, Sharlene Calorossi, Alona Lansky, Laura Walker, Manishkumar Patel, Hui Xie, Nancy Yi, Alex Yu, Gurpawan Kang, Lora E. Liharska, Emily Moya, Matthew Hartnett, Sandra Hatem, Lillian Wilkins, Melody Eaton, Hajra Jamal, Kevin Tuballes, Steven T. Chen, Jonathan Chung, Jocelyn Harris, Craig Batchelor, Jose Lacunza, Mahlet Yishak, Kimberly Argueta, Neha Karekar, Brian Lee, Geoffrey Kelly, Daniel Geanon, Diana Handler, John Leech, Hiyab Stefanos, Travis Dawson, Ieisha Scott, Nancy Francoeur, Jessica S. Johnson, Akhil Vaid, Benjamin S. Glicksberg, Girish N. Nadkarni, Eric E. Schadt, Bruce D. Gelb, Adeeb Rahman, Robert Sebra, Glenn Martin, The Mount Sinai COVID-19 Biobank Team, Thomas Marron, Noam Beckmann, Seunghee Kim-Schulze, Sacha Gnjatic & Miriam Merad

Journal

Nature Medicine

Open Publication

July, 2020

Association of Treatment Dose Anticoagulation with In-Hospital Survival Among Hospitalized Patients with COVID-19

Journal | Journal of the American College of Cardiology

HPI·MS Authors

Alex Charney

Zahi Fayad

Girish Nadkarni

3 HPI•MS authors

Full list of authors

Ishan Paranjpe, Valentin Fuster, Anuradha Lala, Adam Russak, Benjamin S Glicksberg, Matthew A Levin , Alexander W Charney, Jagat Narula, Zahi A Fayad, Emilia Bagiella, Shan Zhao, Girish N Nadkarni

Journal

Journal of the American College of Cardiology

Open Publication

June, 2020

Coronavirus 2019 and People Living With Human Immunodeficiency Virus: Outcomes for Hospitalized Patients in New York City

Journal | Clinical Infectious Diseases

HPI·MS Authors

Erwin Bottinger

Zahi Fayad

Alex Charney

Girish Nadkarni

4 HPI•MS authors

Full list of authors

Keith Sigel, Talia Swartz, Eddye Golden, Ishan Paranjpe, Sulaiman Somani, Felix Richter, Jessica K De Freitas, Riccardo Miotto, Shan Zhao, Paz Polak, Tinaye Mutetwa, Stephanie Factor, Saurabh Mehandru, Michael Mullen, Francesca Cossarini, Erwin Bottinger, Zahi Fayad, Miriam Merad, Sacha Gnjatic, Judith Aberg, Alexander Charney, Girish Nadkarni, Benjamin S Glicksberg

Journal

Clinical Infectious Diseases

Open Publication

April, 2020

Clinical Characteristics of Hospitalized COVID-19 Patients in New York City

Journal | medRxiv

HPI·MS Authors

Matteo Danieletto

Manbir Singh

Zahi Fayad

Erwin Bottinger

Alex Charney

Girish Nadkarni

6 HPI•MS authors

Full list of authors

Ishan Paranjpe, Adam Russak, Jessica K De Freitas, Anuradha Lala, Riccardo Miotto, Akhil Vaid, Kipp W Johnson, Matteo Danieletto, Eddye Golden, Dara Meyer, Manbir Singh, Sulaiman Somani, Sayan Manna, Udit Nangia, Arjun Kapoor, Ross O'Hagan, Paul F O'Reilly, Laura M Huckins, Patricia Glowe, Arash Kia, Prem Timsina, Robert M Freeman, Matthew A Levin, Jeffrey Jhang, Adolfo Firpo, Patricia Kovatch, Joseph Finkelstein, Judith A Aberg, Emilia Bagiella, Carol R Horowitz, Barbara Murphy, Zahi A Fayad, Jagat Narula, Eric J Nestler, Valentin Fuster, Carlos Cordon-Cardo, Dennis S Charney, David L Reich, Allan C Just, Erwin P Bottinger, Alexander W Charney, Benjamin S Glicksberg, Girish Nadkarni, Mount Sinai Covid Informatics Center

Journal

medRxiv

Open Publication